Sarcević B
University Hospital for Tumors, 10000 Zagreb, Croatia.
Acta Med Croatica. 2001;55(4-5):187-90.
Angiogenesis is the formation of new blood vessels from the existing vascular network. It is a complex, multi-step process involving extracellular matrix remodeling, endothelial cell migration and proliferation, capillary differentiation, and anastomoses. Angiogenesis is crucial for tumor progression and metastasizing. Intratumor microvessel density is believed to reflect the degree of angiogenesis in carcinomas. Angiogenesis is also very important in many preneoplastic lesions.
血管生成是指从现有血管网络形成新的血管。它是一个复杂的多步骤过程，涉及细胞外基质重塑、内皮细胞迁移和增殖、毛细血管分化以及吻合。血管生成对于肿瘤进展和转移至关重要。肿瘤内微血管密度被认为反映了癌组织中血管生成的程度。血管生成在许多癌前病变中也非常重要。
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