组蛋白H4过表达可抑制SIR2诱导的细胞 inviability（此处inviability未明确准确中文含义，可根据上下文进一步确定，暂保留英文）。
SIR2-induced inviability is suppressed by histone H4 overexpression.
作者信息
Matecic Mirela, Stuart Shelagh, Holmes Scott G
机构信息
Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut 06459, USA.
出版信息
Genetics. 2002 Oct;162(2):973-6. doi: 10.1093/genetics/162.2.973.
Abstract
We have identified histone H4 as a high-expression suppressor of Sir2-induced inviability in yeast cells. Overexpression of histone H3 does not suppress Sir2-induced lethality, nor does overexpression of histone H4 alleles associated with silencing defects. These results suggest a direct and specific interaction between Sir2 and H4 in the silencing mechanism.
摘要
我们已确定组蛋白H4是酵母细胞中Sir2诱导的致死性的高表达抑制因子。组蛋白H3的过表达不会抑制Sir2诱导的致死性，与沉默缺陷相关的组蛋白H4等位基因的过表达也不会。这些结果表明在沉默机制中Sir2与H4之间存在直接且特异性的相互作用。
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