Legrand C
J Gynecol Obstet Biol Reprod (Paris). 1975 Nov-Dec;4(8):1017-35.
The ultrastructural study of the intra-arterial trophoblast has revealed in the pregnant Rat a steroidogenic activity which has been confirmed by histoenzymologic observations (presence of delta 5-3 beta-HSDH and 17 beta-HSDH). At the 15th day postcoitum an in vitro investigation upon the metabolism of steroid hormone precursors suggests that the steroids (oestrogens, progestogens and androgens) secreted by the intra-arterial trophoblast have a local action upon the wall of the uterine placental arteries and are actively concerned with an important part upon the utero-placental hemodynamic as a whole.
对动脉内滋养层细胞的超微结构研究显示，怀孕大鼠体内存在类固醇生成活性，这一点已通过组织酶学观察得到证实（存在δ5-3β-羟基类固醇脱氢酶和17β-羟基类固醇脱氢酶）。在交配后第15天，对类固醇激素前体代谢的体外研究表明，动脉内滋养层细胞分泌的类固醇（雌激素、孕激素和雄激素）对子宫胎盘动脉壁具有局部作用，并在整个子宫胎盘血液动力学中发挥重要作用。
