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[大鼠动脉内滋养层细胞的类固醇生成功能。超微结构、组织酶学和生化数据]

[Steroidogenic function of the intra-arterial trophoblast in the rat. Ultrastructural, histoenzymologic and biochemical data].

作者信息

Legrand C

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1975 Nov-Dec;4(8):1017-35.

PMID:1240105
Abstract

The ultrastructural study of the intra-arterial trophoblast has revealed in the pregnant Rat a steroidogenic activity which has been confirmed by histoenzymologic observations (presence of delta 5-3 beta-HSDH and 17 beta-HSDH). At the 15th day postcoitum an in vitro investigation upon the metabolism of steroid hormone precursors suggests that the steroids (oestrogens, progestogens and androgens) secreted by the intra-arterial trophoblast have a local action upon the wall of the uterine placental arteries and are actively concerned with an important part upon the utero-placental hemodynamic as a whole.

摘要

对动脉内滋养层细胞的超微结构研究显示,怀孕大鼠体内存在类固醇生成活性,这一点已通过组织酶学观察得到证实(存在δ5-3β-羟基类固醇脱氢酶和17β-羟基类固醇脱氢酶)。在交配后第15天,对类固醇激素前体代谢的体外研究表明,动脉内滋养层细胞分泌的类固醇(雌激素、孕激素和雄激素)对子宫胎盘动脉壁具有局部作用,并在整个子宫胎盘血液动力学中发挥重要作用。

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