Lyons Rachel A, Djahanbakhch Ovrang, Saridogan Ertan, Naftalin Alan A, Mahmood Tariq, Weekes Anthony, Chenoy Rashna
Academic Department of Obstetrics and Gynaecology, St Bartholomew's Hospital and The London School of Medicine and Dentistry, London, UK.
Lancet. 2002 Oct 19;360(9341):1221-2. doi: 10.1016/S0140-6736(02)11247-5.
Endometriosis and infertility are known to be associated, but it is unclear whether endometriosis causes infertility. We used contrast analogue enhancement to study the effect of peritoneal fluid from women with early stage endometriosis on the ciliary beat frequency of human fallopian tube epithelium. We obtained peritoneal fluid from six women with early stage endometriosis and from six fertile women with no evidence of endometriosis to use as controls. Fallopian tubes from hysterectomy specimens were collected from 17 women. The difference in ciliary beat frequency between fallopian tubes exposed to peritoneal fluids of women with and without endometriosis increased with the duration of incubation (mean difference at 24 h 1.35 Hz, 95% CI 0.94-1.75, p=0.01). At 24 h, ciliary beat frequency was significantly lower in the incubations with peritoneal fluid from women with endometriosis than controls (4.29 [0.15] vs 5.64 Hz [0.15], respectively, p=0.001). Impairment of ciliary action in women with endometriosis might reduce fertility.
子宫内膜异位症与不孕症之间的关联已为人所知，但子宫内膜异位症是否会导致不孕尚不清楚。我们使用对比模拟增强技术来研究早期子宫内膜异位症女性的腹腔液对人输卵管上皮纤毛摆动频率的影响。我们从六名早期子宫内膜异位症女性和六名无子宫内膜异位症迹象的可育女性中获取腹腔液作为对照。从17名女性的子宫切除标本中收集输卵管。暴露于有和没有子宫内膜异位症女性腹腔液的输卵管之间的纤毛摆动频率差异随着孵育时间的延长而增加（24小时时平均差异为1.35Hz，95%CI为0.94 - 1.75，p = 0.01）。在24小时时，与来自无子宫内膜异位症女性腹腔液孵育的情况相比，与来自有子宫内膜异位症女性腹腔液孵育的纤毛摆动频率显著更低（分别为4.29[0.15]Hz和5.64Hz[0.15]，p = 0.001）。子宫内膜异位症女性的纤毛活动受损可能会降低生育能力。
