Riedel Wim J, Klaassen Tineke, Schmitt Jeroen A J
Experimental Psychopharmacology Unit, Brain & Behaviour Institute, Universiteit Maastricht, The Netherlands.
Brain Behav Immun. 2002 Oct;16(5):581-9. doi: 10.1016/s0889-1591(02)00013-2.
In separate experiments we investigated the duration of the effects of acute tryptophan depletion (ATD) on mood and cognition. The results showed that ATD's effects consist of lowering of mood only in subjects with a family history of unipolar depression. A specific impairment of memory consolidation was seen in all subjects. In subjects without any vulnerability for mood disorders, performance on so-called 'frontal tasks,' measuring higher attentional functions tended to improve after ATD. The effects of ATD on mood and cognition were manifest as long as biochemical indices of low tryptophan remained low. In conclusion, ATD is a model for impairment of memory, next to being a model of mood disorders in vulnerable subjects. Moreover, ATD could be used as a challenge to demonstrate individual vulnerability of the serotonergic system.
在单独的实验中，我们研究了急性色氨酸耗竭（ATD）对情绪和认知的影响持续时间。结果表明，ATD的影响仅表现为在有单相抑郁症家族史的受试者中情绪低落。在所有受试者中均观察到记忆巩固的特定损害。在没有任何情绪障碍易感性的受试者中，测量更高注意力功能的所谓“额叶任务”的表现往往在ATD后有所改善。只要低色氨酸的生化指标保持较低水平，ATD对情绪和认知的影响就会显现出来。总之，ATD除了是易患情绪障碍受试者的情绪障碍模型外，还是一种记忆损害模型。此外，ATD可作为一种激发手段，以证明5-羟色胺能系统的个体易感性。
