Kolomiytseva I K, Kulagina T P, Markevich L N, Archipov V I, Slozhenikina L V, Fialkovskaya L A, Potekhina N I
Institute of Cell Biophysics RAS, 142290 Pushchino, Moscow, Russia.
Bioelectrochemistry. 2002 Nov;58(1):31-9. doi: 10.1016/s1567-5394(02)00126-3.
The data on nuclear and chromatin lipid metabolism are reviewed. The amount of neutral lipids and phospholipids in nuclei of rat thymus, liver and neocortex neuron as well as the amount of lipids in rat thymus and liver chromatin are described. The metabolic responses of nuclear and chromatin lipids from thymus to different doses and dose rates of gamma-irradiation of rats are discussed. In most cases, the nuclear and chromatin lipid responses are distinct. Changes in nuclear and chromatin lipid metabolism in response to gamma-irradiation are suggested to connect with the signal transduction pathway and the regulation of the transcriptional and replicative chromatin activity. The influence of beta-carotene and picrotoxin on rat liver nuclear lipids and neocortex neuronal nuclear lipids, respectively, was analyzed. The possible involvement of the lipid traffic in the chromatin lipid responses to gamma-irradiation and other agents is suggested.
本文综述了有关细胞核和染色质脂质代谢的数据。描述了大鼠胸腺、肝脏和新皮质神经元细胞核中的中性脂质和磷脂含量，以及大鼠胸腺和肝脏染色质中的脂质含量。讨论了大鼠胸腺细胞核和染色质脂质对不同剂量和剂量率γ射线照射的代谢反应。在大多数情况下，细胞核和染色质脂质反应是不同的。γ射线照射引起的细胞核和染色质脂质代谢变化被认为与信号转导途径以及转录和复制染色质活性的调节有关。分别分析了β-胡萝卜素和印防己毒素对大鼠肝脏细胞核脂质和新皮质神经元细胞核脂质的影响。提示脂质转运可能参与染色质脂质对γ射线照射和其他因素的反应。
