Turan A, Karamanlýoglu B, Memis D, Kaya G, Pamukçu Z
Department of Anaesthesiology and Reanimation, Medical Faculty, Trakya University, 22030 Edirne, Turkey.
Anesth Analg. 2002 Nov;95(5):1419-22, table of contents. doi: 10.1097/00000539-200211000-00058.
Neostigmine has been added to local anesthetics for central and peripheral nerve blocks resulting in prolonged, increased anesthesia and improved analgesia. We conducted this study to evaluate the effects of neostigmine when added to prilocaine for IV regional anesthesia (IVRA). Thirty patients undergoing hand surgery were randomly assigned to two groups to receive IVRA. The control group received 1 mL of saline plus 3 mg/kg of prilocaine diluted with saline to a total dose of 40 mL; the study group received 0.5 mg of neostigmine plus 3 mg/kg of prilocaine diluted with saline to a total dose of 40 mL. Sensory and motor block onset and recovery, anesthesia quality determined by an anesthesiologist, anesthesia quality determined by a surgeon, and dryness of the operative field were noted. Heart rate, mean arterial blood pressure, and oxygen saturation values were noted at 1, 5, 10, 20, and 40 min before surgery and after tourniquet release. Time to first analgesic requirement was also noted. Shortened sensory and motor block onset times, prolonged sensory and motor block recovery times, improved quality of anesthesia, and prolonged time to first analgesic requirement were found in the neostigmine group. We conclude that neostigmine as an adjunct to prilocaine improves quality of anesthesia and is beneficial in IVRA.
Neostigmine has been added to local anesthetics for central and peripheral nerve blocks. This study was conducted to evaluate the effects of neostigmine when added to prilocaine for IV regional anesthesia (IVRA). Neostigmine as an adjunct to prilocaine improves quality of anesthesia and is beneficial in IVRA.
新斯的明已被添加到用于中枢和周围神经阻滞的局部麻醉剂中，可延长麻醉时间、增强麻醉效果并改善镇痛作用。我们开展本研究以评估新斯的明添加到丙胺卡因用于静脉区域麻醉（IVRA）时的效果。30例行手部手术的患者被随机分为两组接受IVRA。对照组接受1 mL生理盐水加3 mg/kg丙胺卡因，用生理盐水稀释至总量40 mL；研究组接受0.5 mg新斯的明加3 mg/kg丙胺卡因，用生理盐水稀释至总量40 mL。记录感觉和运动阻滞的起效及恢复情况、麻醉医生判定的麻醉质量、外科医生判定的麻醉质量以及术野干燥情况。记录手术前及松开止血带后1、5、10、20和40分钟时的心率、平均动脉血压和血氧饱和度值。还记录首次需要镇痛的时间。新斯的明组的感觉和运动阻滞起效时间缩短、感觉和运动阻滞恢复时间延长、麻醉质量改善且首次需要镇痛的时间延长。我们得出结论，新斯的明作为丙胺卡因的辅助用药可改善麻醉质量，在IVRA中有益。
新斯的明已被添加到用于中枢和周围神经阻滞的局部麻醉剂中。本研究旨在评估新斯的明添加到丙胺卡因用于静脉区域麻醉（IVRA）时的效果。新斯的明作为丙胺卡因的辅助用药可改善麻醉质量，在IVRA中有益。
