Choi Sungshin Y, Hirata Ken-ichi, Ishida Tatsuro, Quertermous Thomas, Cooper Allen D
Palo Alto Medical Foundation, Research Institute, Palo Alto, CA 94301, USA.
J Lipid Res. 2002 Nov;43(11):1763-9. doi: 10.1194/jlr.r200011-jlr200.
Endothelial lipase (EL) is a newly described member of the triglyceride lipase gene family. It has a considerable molecular homology with lipoprotein lipase (LPL) (44%) and hepatic lipase (HL) (41%). Unlike LPL and HL, this enzyme is synthesized by endothelial cells and functions at the site where it is synthesized. Furthermore, its tissue distribution is different from that of LPL and HL. As a lipase, EL has primarily phospholipase A1 activity. Animals that overexpress EL showed reduced HDL cholesterol levels. Conversely, animals that are deficient in EL showed a marked elevation in HDL cholesterol levels, suggesting that it plays a physiologic role in HDL metabolism. Unlike LPL and HL, EL is located in the vascular endothelial cells and its expression is highly regulated by cytokines and physical forces, suggesting that it may play a role in the development of atherosclerosis. However, there is only a limited amount of information available about this enzyme. Some of our unpublished data in addition to previously published data support the possibility that the enzyme plays a role in the formation of atherosclerotic lesion.
内皮脂肪酶（EL）是甘油三酯脂肪酶基因家族新发现的成员。它与脂蛋白脂肪酶（LPL）（44%）和肝脂肪酶（HL）（41%）有相当程度的分子同源性。与LPL和HL不同，这种酶由内皮细胞合成，并在合成部位发挥作用。此外，其组织分布与LPL和HL不同。作为一种脂肪酶，EL主要具有磷脂酶A1活性。过度表达EL的动物显示高密度脂蛋白胆固醇水平降低。相反，缺乏EL的动物显示高密度脂蛋白胆固醇水平显著升高，这表明它在高密度脂蛋白代谢中发挥生理作用。与LPL和HL不同，EL位于血管内皮细胞中，其表达受细胞因子和物理力的高度调节，这表明它可能在动脉粥样硬化的发展中起作用。然而，关于这种酶的信息有限。除了先前发表的数据外，我们一些未发表的数据支持该酶在动脉粥样硬化病变形成中起作用的可能性。
