Cilingiroglu Mehmet, Ballantyne Christie
Section of Cardiology and Atherosclerosis, Baylor College of Medicine, One Baylor Plaza, Jewish Building 519-D, Houston, TX 77030, USA.
Curr Atheroscler Rep. 2004 Mar;6(2):126-30. doi: 10.1007/s11883-004-0101-y.
Endothelial lipase (EL), a new member of the lipase gene family, was recently cloned and has a significant role in plasma high-density lipoprotein levels (HDL). EL has a highly similar molecular homology to lipoprotein lipase and hepatic lipase. It is synthesized by endothelial cells and functions at the cell surface. EL primarily has phospholipase A1 activity. Animals that overexpress EL showed decreased HDL cholesterol levels and those that lack EL show elevated levels of HDL cholesterol. The expression is highly regulated by cytokines and physical forces. These data suggest that EL may play a significant role in atherosclerosis.
内皮脂肪酶（EL）是脂肪酶基因家族的一个新成员，最近被克隆出来，在血浆高密度脂蛋白（HDL）水平中起重要作用。EL与脂蛋白脂肪酶和肝脂肪酶具有高度相似的分子同源性。它由内皮细胞合成并在细胞表面发挥作用。EL主要具有磷脂酶A1活性。过度表达EL的动物显示HDL胆固醇水平降低，而缺乏EL的动物则显示HDL胆固醇水平升高。其表达受到细胞因子和物理力的高度调节。这些数据表明EL可能在动脉粥样硬化中起重要作用。
