Hu Ke, Yao Xinsheng
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 14260, USA.
Phytomedicine. 2002 Sep;9(6):560-5. doi: 10.1078/09447110260573218.
Protoneodioscin (NSC-698789) is a furostanol saponin isolated from the rhizomes of Dioscorea collettii var. hypoglauca (Dioscoreaceae), a Chinese herbal remedy for cancer treatment. Our studies showed that protoneodioscin is cytotoxic against most cell lines from leukemia and solid tumors in the NCI's (National Cancer Institute, USA) anticancer drug screen. Leukemia, CNS cancer, and prostate cancer are the most sensitive subpanels to protoneodioscin, while melanoma, ovarian cancer, and renal cancer are less sensitive. The preliminary animal studies showed that the maximum tolerant dose of protoneodioscin was 600 mg/kg to mice. Based on an analysis of the COMPARE software with protoneodioscin as a seed compound, no compounds in the NCI's database have similar cytotoxicity patterns to those of protoneodioscin, indicating a potentially novel mechanism of anticancer action involved.
原新薯蓣皂苷（NSC - 698789）是从粉背薯蓣（薯蓣科）根茎中分离得到的呋甾烷醇皂苷，粉背薯蓣是一种用于癌症治疗的中草药。我们的研究表明，在国立癌症研究所（美国）的抗癌药物筛选中，原新薯蓣皂苷对大多数白血病和实体瘤细胞系具有细胞毒性。白血病、中枢神经系统癌症和前列腺癌是对原新薯蓣皂苷最敏感的亚组，而黑色素瘤、卵巢癌和肾癌则不太敏感。初步动物研究表明，原新薯蓣皂苷对小鼠的最大耐受剂量为600mg/kg。以原新薯蓣皂苷为种子化合物进行COMPARE软件分析，国立癌症研究所数据库中没有化合物具有与原新薯蓣皂苷相似的细胞毒性模式，这表明其抗癌作用可能涉及一种新机制。
