Stone Katherine M, Karem Kevin L, Sternberg Maya R, McQuillan Geraldine M, Poon Alysia D, Unger Elizabeth R, Reeves William C
Division of STD Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
J Infect Dis. 2002 Nov 15;186(10):1396-402. doi: 10.1086/344354. Epub 2002 Oct 21.
Infection with human papillomavirus (HPV) type 16 accounts for about half of cervical cancers worldwide. This study investigated the seroepidemiology of HPV-16 infection in the United States by using a population-based survey. Serum samples and questionnaire data were collected from 1991 to 1994 for the National Health and Nutrition Examination Surveys. HPV-16-specific IgG antibody was detected by use of an HPV-16 virus-like particle ELISA. HPV-16 seropositivity in the US population aged 12-59 years was 13.0% (95% confidence interval, 11.5%-14.7%). Seroprevalence was higher in women (17.9%) than in men (7.9%). Age, race/ethnicity, and number of lifetime sex partners were associated with HPV seropositivity in women. Race/ethnicity, age at first intercourse, urban/nonurban residence, years of sexual activity, and having had sex with a man were associated with HPV seropositivity in men. Information on HPV-16 seroepidemiology will be important for designing prevention efforts including vaccine programs.
16型人乳头瘤病毒（HPV）感染导致了全球约一半的宫颈癌。本研究通过一项基于人群的调查，对美国HPV-16感染的血清流行病学进行了调查。在1991年至1994年期间，为全国健康和营养检查调查收集了血清样本和问卷数据。使用HPV-16病毒样颗粒酶联免疫吸附测定法检测HPV-16特异性IgG抗体。在美国12至59岁人群中，HPV-16血清阳性率为13.0%（95%置信区间为11.5%-14.7%）。女性的血清阳性率（17.9%）高于男性（7.9%）。年龄、种族/族裔以及终身性伴侣数量与女性的HPV血清阳性有关。种族/族裔、首次性交年龄、城乡居住情况、性活动年限以及与男性发生性行为与男性的HPV血清阳性有关。HPV-16血清流行病学信息对于设计包括疫苗项目在内的预防措施至关重要。
