16型人乳头瘤病毒在儿童中的血清流行率。

Seroprevalence of human papillomavirus type 16 in children.

作者信息

Dunne Eileen F, Karem Kevin L, Sternberg Maya R, Stone Katherine M, Unger Elizabeth R, Reeves William C, Markowitz Lauri E

机构信息

Division of STD Prevention, National Center for HIV, STD, and TB Prevention, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

J Infect Dis. 2005 Jun 1;191(11):1817-9. doi: 10.1086/430274. Epub 2005 May 2.

DOI:10.1086/430274

PMID:15871113

Abstract

We evaluated the prevalence of antibodies to human papillomavirus (HPV) type 16 in a representative sample of children 6-11 years of age in the United States. Serum samples and questionnaire data were collected between 1991 and 1994, for the National Health and Nutrition Examination Survey III. HPV-16-specific immunoglobulin G antibodies were detected by an HPV-16 L1 virus-like particle-based enzyme-linked immunosorbant assay. Overall, 2.4% of 1316 children 6-11 years of age were seropositive. Seroprevalence was higher in boys than in girls (3.5% vs. 1.2%; P=.08) and in children >7 years of age than in children < or =7 years of age (3.3% vs. 0.4%; P<.05). None of the variables tested for, including race/ethnicity, socioeconomic status, and urban or rural residence, were significantly associated with HPV-16 seropositivity. To explain HPV-16 seropositivity in this population, further study is required.

摘要

我们评估了美国6至11岁儿童代表性样本中人乳头瘤病毒16型（HPV-16）抗体的流行情况。1991年至1994年期间，为第三次全国健康和营养检查调查收集了血清样本和问卷数据。通过基于HPV-16 L1病毒样颗粒的酶联免疫吸附测定法检测HPV-16特异性免疫球蛋白G抗体。总体而言，1316名6至11岁儿童中有2.4%呈血清阳性。男孩的血清阳性率高于女孩（3.5%对1.2%；P = 0.08），7岁以上儿童的血清阳性率高于7岁及以下儿童（3.3%对0.4%；P < 0.05）。所检测的变量，包括种族/族裔、社会经济地位以及城市或农村居住情况，均与HPV-16血清阳性无显著关联。为解释该人群中HPV-16血清阳性情况，需要进一步研究。