Allali Malika, Errafii Khaoula, El Fermi Rachid, Messaoudi Nouha, Fichtali Karima, El Fazazi Hicham, El Ghanmi Adil, El Majjaoui Sanaa, Ismaili Nabil, Wakrim Lahcen, Al Idrissi Najib, Rhalem Abdelaziz Wajih, Ghazi Bouchra, Ouladlahsen Ahd, Bakri Youssef, Ghazal Hassan, Hamdi Salsabil
Virology and Public Health Laboratory, Centre de Serums et Vaccins (Institut Pasteur du Maroc), Casablanca, Morocco.
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
Pan Afr Med J. 2025 Mar 28;50:87. doi: 10.11604/pamj.2025.50.87.45024. eCollection 2025.
Cervical cancer (CC) is one of the most common malignancies among women in Morocco. This study aims to evaluate the risk factors associated with CC in Moroccan women aged 18 to 62.
this was a case-control study of 169 women who received radio-chemotherapy and 100 controls. Statistical analyses were performed using SPSS version 29.0.10 to determine associated factors at a significance level of ≤0.05.
significant associations were found between CC and the following factors: educational level (OR= 9.167), sexual activity during menstruation (OR= 2.351), previous occurrences of sexually transmitted infections (OR= 2.173), and history of multiple sexual partners by the husband (OR= 6.305). However, family history of cancer, consanguinity, number of sleeping hours, and stress did not show any significant association with CC. HPV infection was detected in 33.81% of cases and 8% of controls, with HPV16 being the most prevalent genotype (59.57%), followed by HPV53 (14.79%). Other genotypes were found at lower frequencies. The phylogenetic analysis of HPV isolates showed that the distribution of HPV sequences in Moroccan women with cervical cancer is mainly linked to European, Saudi Arabian and North African epidemiological conditions, suggesting recombinant HPV forms. Additionally, American isolates formed two distinct outgroups, likely due to geographical distance, indicating variations in HPV strains by region.
Morocco faces a significant burden of CC, with HPV being the primary cause. Lifestyle risk factors like low education, male sexual behavior, multiple pregnancies, and sexual intercourse also contribute.
宫颈癌（CC）是摩洛哥女性中最常见的恶性肿瘤之一。本研究旨在评估18至62岁摩洛哥女性中与宫颈癌相关的危险因素。
这是一项病例对照研究，涉及169名接受放化疗的女性和100名对照者。使用SPSS 29.0.10版进行统计分析，以确定显著性水平≤0.05的相关因素。
发现宫颈癌与以下因素之间存在显著关联：教育程度（OR = 9.167）、经期性行为（OR = 2.351）、既往性传播感染史（OR = 2.173）以及丈夫有多个性伴侣史（OR = 6.305）。然而，癌症家族史、近亲结婚、睡眠时间和压力与宫颈癌未显示出任何显著关联。在33.81%的病例和8%的对照者中检测到HPV感染，其中HPV16是最常见的基因型（59.57%），其次是HPV53（14.79%）。其他基因型的频率较低。对HPV分离株的系统发育分析表明，摩洛哥宫颈癌女性中HPV序列的分布主要与欧洲、沙特阿拉伯和北非的流行病学情况相关，提示存在重组HPV形式。此外，美国的分离株形成了两个不同的外群，可能是由于地理距离，表明HPV菌株存在区域差异。
摩洛哥面临着严重的宫颈癌负担，HPV是主要原因。低教育程度、男性性行为、多次怀孕和性交等生活方式危险因素也有影响。
