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新手、中度和重度娱乐性使用者报告的摇头丸/3,4-亚甲基二氧甲基苯丙胺所致问题。

Ecstasy/MDMA attributed problems reported by novice, moderate and heavy recreational users.

作者信息

Parrott A C, Buchanan T, Scholey A B, Heffernan T, Ling J, Rodgers J

机构信息

Recreational Drugs Research Group, School of Psychology, University of East London, London E15 4LZ, UK.

出版信息

Hum Psychopharmacol. 2002 Aug;17(6):309-12. doi: 10.1002/hup.415.

Abstract

RATIONALE

The recreational use of MDMA/Ecstasy (3,4-methylenedioxymethamphetamine) is associated with many psychobiological problems, but there is a paucity of data on how these relate to the level of past use.

OBJECTIVES

to assess the incidence of Ecstasy-attributed problems as reported by novice, moderate and heavy users.

METHODS

763 unpaid volunteers took part in a WWW study of recreational drug use. This report is based on the 282 Ecstasy users from that sample, who comprised 109 novice users (1-9 occasions), 136 moderate users (10-99 occasions), and 36 heavy users (+100 occasions). Yes/no responses were automatically recorded to a series of questions covering psychobiological problems experienced when drug-free, which were attributed by the respondents to their Ecstasy use.

RESULTS

Depression, memory problems, anxiety, mood fluctuation, poor concentration, infections, tremors/twitches and weight loss, were all significantly associated with the extent of Ecstasy use. Thus memory problems attributed to Ecstasy were reported by 19% of novice users, 52% of heavy users and 73% of heavy users (chi-square 42.74, df=2, p<0.001); many of the other variables showed similar trends.

CONCLUSIONS

The incidence of problems attributed to Ecstasy use, is directly related to the number of occasions it has been used.

摘要

理论依据

摇头丸/迷幻药(3,4-亚甲基二氧甲基苯丙胺)的娱乐性使用与许多心理生物学问题相关,但关于这些问题如何与过去的使用水平相关的数据却很少。

目的

评估新手、中度使用者和重度使用者报告的由摇头丸引起的问题的发生率。

方法

763名无报酬志愿者参与了一项关于娱乐性药物使用的网络研究。本报告基于该样本中的282名摇头丸使用者,其中包括109名新手使用者(1 - 9次)、136名中度使用者(10 - 99次)和36名重度使用者(+100次)。针对一系列关于在未使用药物时所经历的心理生物学问题的问题,自动记录“是/否”回答,这些问题由受访者归因于他们使用摇头丸所致。

结果

抑郁、记忆问题、焦虑、情绪波动、注意力不集中、感染、震颤/抽搐和体重减轻,均与摇头丸的使用程度显著相关。因此,19%的新手使用者、52%的中度使用者和73%的重度使用者报告称存在归因于摇头丸的记忆问题(卡方检验42.74,自由度 = 2,p < 0.001);许多其他变量也呈现出类似趋势。

结论

归因于摇头丸使用的问题发生率与使用次数直接相关。

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