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Short-term treatment of post-traumatic stress disorder with naltrexone: an open-label preliminary study.

作者信息

Lubin Gad, Weizman Abraham, Shmushkevitz Mordechai, Valevski Avi

机构信息

Geha Psychiatric Hospital, and Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel.

出版信息

Hum Psychopharmacol. 2002 Jun;17(4):181-5. doi: 10.1002/hup.395.

DOI:10.1002/hup.395
PMID:12404685
Abstract

Eight patients (6 men and 2 women) with chronic post-traumatic stress disorder (PTSD) were treated with naltrexone 100-200 mg/day. Seven patients completed 2 weeks of treatment. A subtle and clinically insignificant improvement was noted in intrusive and hyperarousal symptoms (p < 0.05 for both), but not in avoidance symptoms. All patients demonstrated side effects which limited the targeted dose. It is suggested that the subtle positive effect of naltrexone and the hypersensitivity of these patients to its side effects do not encourage the use of naltrexone in the treatment of PTSD patients.

摘要

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