Del Arco Ignacio, Navarro Miguel, Bilbao Ainhoa, Ferrer Belén, Piomelli Daniele, Rodríguez De Fonseca Fernando
Fundación Hospital Carlos Haya, Avda Carlos Haya 82. 7 Planta, Pabellón A., Málaga 29010, Spain.
Eur J Pharmacol. 2002 Nov 1;454(1):103-4. doi: 10.1016/s0014-2999(02)02483-4.
The endogenous cannabinoid, anandamide, has been shown to attenuate naloxone-precipitated opiate withdrawal in rodents. Here we show that the spontaneous, but not the naloxone-precipitated withdrawal syndrome in morphine-dependent mice is attenuated by the inhibitor of carrier-mediated anandamide transport N-(4-hydroxyphenyl) arachidonylethanolamide (AM404) (2 and 10 mg/kg, i.p.). These results suggest that spontaneous but not opioid antagonist-precipitated withdrawal is associated with dynamic changes in endogenous cannabinoid signaling.
