空肠弯曲菌肠炎后出现的伴有抗GT1a IgG抗体的急性孤立性延髓麻痹。

Acute isolated bulbar palsy with anti-GT1a IgG antibody subsequent to Campylobacter jejuni enteritis.

作者信息

Onodera Masakazu, Mori Masahiro, Koga Michiaki, Kamitsukasa Ikuo, Fukutake Toshio, Hattori Takamichi, Yuki Nobuhiro, Kuwabara Satoshi

机构信息

Department of Neurology, Chiba Rosai Hospital, Chiba, Japan.

出版信息

J Neurol Sci. 2002 Dec 15;205(1):83-4. doi: 10.1016/s0022-510x(02)00241-1.

DOI:10.1016/s0022-510x(02)00241-1

PMID:12409189

Abstract

We describe a patient with acute isolated bulbar palsy following enteritis. A 29-year-old man developed dysphagia and nasal voice without limb weakness, ataxia, or areflexia. High titres of serum anti-GT1a and anti-Campylobacter jejuni IgG antibodies were detected. He was treated with plasmapheresis, resulting in rapid clinical improvement. This case suggests that an acute isolated bulbar palsy may be caused by a pathology relating to Guillain-Barré syndrome (GBS), in which anti-GT1a IgG antibody may have a role.

摘要

我们描述了一名患肠炎后出现急性孤立性延髓麻痹的患者。一名29岁男性出现吞咽困难和鼻音，无肢体无力、共济失调或反射消失。检测到高滴度的血清抗GT1a和抗空肠弯曲菌IgG抗体。他接受了血浆置换治疗，临床症状迅速改善。该病例表明，急性孤立性延髓麻痹可能由与吉兰-巴雷综合征（GBS）相关的病理引起，其中抗GT1a IgG抗体可能起作用。