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Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy.

作者信息

Clerici Mario, Saresella Marina, Trabattoni Daria, Ferrante Pasquale, Vanzulli Angelo, Vigano Alessandra

机构信息

Department of Immunology, Milan University, Italy.

出版信息

AIDS. 2002 Nov 8;16(16):2219-21. doi: 10.1097/00002030-200211080-00015.

DOI:10.1097/00002030-200211080-00015
PMID:12409744
Abstract
摘要

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Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy.胸腺体积可预测接受高效抗逆转录病毒治疗的HIV感染儿童的长期免疫重建。
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2
Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy.长期抗逆转录病毒治疗后,HIV 感染患者免疫重建失败的主要机制是胸腺输出减少。
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Baseline thymic volume is a predictor for CD4 T cell repopulation in adult HIV-infected patients under highly active antiretroviral therapy.基线胸腺体积是接受高效抗逆转录病毒治疗的成年HIV感染患者CD4 T细胞再增殖的一个预测指标。
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Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART.对高效抗逆转录病毒治疗(HAART)产生免疫病毒学反应不一致的HIV感染患者的T细胞更新和稳态参数的比较分析。
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Endogenous IL-7 is associated with increased thymic volume in adult HIV-infected patients under highly active antiretroviral therapy.内源性白细胞介素-7与接受高效抗逆转录病毒治疗的成年HIV感染患者胸腺体积增加有关。
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CD31+ cell percentage correlation with speed of CD4+ T-cell count recovery in HIV-infected adults is reversed in children: higher thymic output may be responsible.在儿童中,CD31 +细胞百分比与HIV感染成人CD4 + T细胞计数恢复速度的相关性相反:胸腺输出增加可能是原因所在。
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Premature immunosenescence in HIV-infected patients on highly active antiretroviral therapy with low-level CD4 T cell repopulation.接受高效抗逆转录病毒治疗且CD4 T细胞低水平重建的HIV感染患者中存在过早免疫衰老。
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Effects of highly active antiretroviral therapy on thymical reconstitution of CD4 T lymphocytes in vertically HIV-infected children.高效抗逆转录病毒疗法对垂直感染HIV儿童CD4 T淋巴细胞胸腺重建的影响。
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AIDS. 2014 Jul 17;28(11):1645-55. doi: 10.1097/QAD.0000000000000272.
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Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation.HIV-1 感染个体中免疫功能障碍是由腺苷脱氨酶诱导的 T 细胞激活共刺激作用受损引起的。
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Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.
迪乔治综合征和HIV-1感染中的人类T细胞重建。
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Thymic volume is associated independently with the magnitude of short- and long-term repopulation of CD4+ T cells in HIV-infected adults after highly active antiretroviral therapy (HAART).在高效抗逆转录病毒疗法(HAART)后,胸腺体积与HIV感染成人CD4 + T细胞短期和长期再增殖的程度独立相关。
Clin Exp Immunol. 2004 Jun;136(3):501-6. doi: 10.1111/j.1365-2249.2004.02474.x.