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CD31+ cell percentage correlation with speed of CD4+ T-cell count recovery in HIV-infected adults is reversed in children: higher thymic output may be responsible.

作者信息

Lewis Joanna, Walker A Sarah, Klein Nigel, Callard Robin

出版信息

Clin Infect Dis. 2012 Jul;55(2):304-7; author reply 307. doi: 10.1093/cid/cis374. Epub 2012 Apr 4.

DOI:10.1093/cid/cis374
PMID:22491332
Abstract
摘要

相似文献

1
CD31+ cell percentage correlation with speed of CD4+ T-cell count recovery in HIV-infected adults is reversed in children: higher thymic output may be responsible.在儿童中,CD31 +细胞百分比与HIV感染成人CD4 + T细胞计数恢复速度的相关性相反:胸腺输出增加可能是原因所在。
Clin Infect Dis. 2012 Jul;55(2):304-7; author reply 307. doi: 10.1093/cid/cis374. Epub 2012 Apr 4.
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Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy.长期抗逆转录病毒治疗后,HIV 感染患者免疫重建失败的主要机制是胸腺输出减少。
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3
Baseline thymic volume is a predictor for CD4 T cell repopulation in adult HIV-infected patients under highly active antiretroviral therapy.基线胸腺体积是接受高效抗逆转录病毒治疗的成年HIV感染患者CD4 T细胞再增殖的一个预测指标。
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HIV-infected patients with a large thymus maintain higher CD4 counts in a 5-year follow-up study of patients treated with highly active antiretroviral therapy.在一项针对接受高效抗逆转录病毒疗法治疗的患者的5年随访研究中,胸腺较大的HIV感染患者维持着较高的CD4细胞计数。
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Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy.胸腺体积可预测接受高效抗逆转录病毒治疗的HIV感染儿童的长期免疫重建。
AIDS. 2002 Nov 8;16(16):2219-21. doi: 10.1097/00002030-200211080-00015.
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Immunological recovery failure in cART-treated HIV-positive patients is associated with reduced thymic output and RTE CD4+ T cell death by pyroptosis.在接受 cART 治疗的 HIV 阳性患者中,免疫恢复失败与胸腺输出减少和 RTE CD4+T 细胞通过细胞焦亡而死亡有关。
J Leukoc Biol. 2020 Jan;107(1):85-94. doi: 10.1002/JLB.4A0919-235R. Epub 2019 Nov 5.
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Thymic volume is associated independently with the magnitude of short- and long-term repopulation of CD4+ T cells in HIV-infected adults after highly active antiretroviral therapy (HAART).在高效抗逆转录病毒疗法(HAART)后,胸腺体积与HIV感染成人CD4 + T细胞短期和长期再增殖的程度独立相关。
Clin Exp Immunol. 2004 Jun;136(3):501-6. doi: 10.1111/j.1365-2249.2004.02474.x.
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Thymic function in HIV-infection.HIV感染中的胸腺功能。
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Thymic volume predicts CD4 T-cell decline in HIV-infected adults under prolonged treatment interruption.
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Thymic Function as a Predictor of Immune Recovery in Chronically HIV-Infected Patients Initiating Antiretroviral Therapy.胸腺功能作为预测慢性 HIV 感染患者开始抗逆转录病毒治疗后免疫恢复的指标。
Front Immunol. 2019 Feb 5;10:25. doi: 10.3389/fimmu.2019.00025. eCollection 2019.

引用本文的文献

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Recent Thymus Emigrant CD4+ T Cells Predict HIV Disease Progression in Patients With Perinatally Acquired HIV.近期迁出胸腺的CD4+ T细胞可预测围产期感染HIV患者的疾病进展。
Clin Infect Dis. 2016 Apr 15;62(8):1029-1035. doi: 10.1093/cid/ciw030. Epub 2016 Feb 21.
2
Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology.儿科传染病与免疫学中的药代动力学/药效学建模方法
Adv Drug Deliv Rev. 2014 Jun;73(100):127-39. doi: 10.1016/j.addr.2014.01.002. Epub 2014 Jan 17.
3
The immunological and virological consequences of planned treatment interruptions in children with HIV infection.
HIV感染儿童计划性治疗中断的免疫学和病毒学后果。
PLoS One. 2013 Oct 23;8(10):e76582. doi: 10.1371/journal.pone.0076582. eCollection 2013.