Gordon Y Jerold, Mann Rupinder K, Mah Tammy S, Gorin Michael B
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
Cornea. 2002 Nov;21(8):770-3. doi: 10.1097/00003226-200211000-00007.
To evaluate patients' self-assessment of their symptoms and cosmetic appearance after fluorescein-potentiated argon laser treatment (FPAL) for corneal inflammation associated with neovascularization. To describe the objective effects of FPAL therapy on established corneal neovascularization with secondary corneal edema and lipid keratopathy.
Fifteen patients with corneal neovascularization resulting from various infectious and traumatic etiologies were enrolled in an open, nonrandomized pilot study. Treatment consisted of repeated sessions of intravenous fluorescein, a photosensitizer, combined with blue-green argon laser applications to abnormal corneal vessels. Patients completed a written survey to grade their symptoms and cosmetic appearance prior to treatment and at the end of the follow-up period. Objective changes in signs after FPAL treatment were described by two nonmasked ophthalmologists after slit-lamp examinations and review of serial corneal photographs.
Clinical symptoms of blurred vision (p <or= 0.003), photophobia (p <or= 0.03), and cosmetic appearance ( p <or= 0.02) were found to be significantly improved by the patient's subjective assessment survey. There was a trend toward pain reduction (p <or= 0.06) but no apparent reduction in tearing or foreign body sensation (p <or= ns). Objective signs of corneal edema, neovascularization, and lipid keratopathy appeared to be reduced after FPAL therapy.
FPAL therapy for corneal neovascularization, edema, and lipid keratopathy resulted in a significant reduction in symptoms and improved quality of life for 14 of 15 (93%) patients. A controlled clinical trial to confirm the reported improvement in signs observed in this pilot study should be considered.
评估接受荧光素增强氩激光治疗（FPAL）以治疗与新生血管相关的角膜炎症的患者对其症状和外观的自我评估。描述FPAL疗法对已形成的伴有继发性角膜水肿和脂质角膜病变的角膜新生血管的客观效果。
15例因各种感染性和创伤性病因导致角膜新生血管的患者参加了一项开放、非随机的试点研究。治疗包括多次静脉注射荧光素（一种光敏剂），并结合对异常角膜血管进行蓝绿色氩激光照射。患者在治疗前和随访期结束时完成一份书面调查问卷，对其症状和外观进行评分。两名未戴眼罩的眼科医生在裂隙灯检查并查看系列角膜照片后，描述了FPAL治疗后体征的客观变化。
通过患者主观评估调查发现，视力模糊（p≤0.003）、畏光（p≤0.03）和外观（p≤0.02）的临床症状有显著改善。疼痛有减轻趋势（p≤0.06），但流泪或异物感无明显减轻（p≤无显著性差异）。FPAL治疗后，角膜水肿、新生血管和脂质角膜病变的客观体征似乎有所减轻。
FPAL治疗角膜新生血管、水肿和脂质角膜病变使15例患者中的14例（93%）症状显著减轻，生活质量得到改善。应考虑进行一项对照临床试验，以证实本试点研究中观察到的体征改善情况。
