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用于角膜变薄和穿孔的组织工程移植物。

Tectonic grafts for corneal thinning and perforations.

作者信息

Vanathi M, Sharma Namrata, Titiyal Jeewan S, Tandon Radhika, Vajpayee Rasik B

机构信息

Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Cornea. 2002 Nov;21(8):792-7. doi: 10.1097/00003226-200211000-00013.

DOI:10.1097/00003226-200211000-00013
PMID:12410039
Abstract

PURPOSE

To evaluate the success of tectonic grafts in cases of corneal thinning and perforations.

METHODS

We performed 42 tectonic grafts in 41 eyes of 40 patients. Three types of tectonic grafts were used in our treatment protocol. These were (a) full-thickness grafts, (b) mushroom grafts, and (c) lamellar grafts. The parameters evaluated were indications, visual acuity, location, size and type of graft, postoperative outcome, and complications, if any.

RESULTS

The most common indication for tectonic grafts was corneal thinning and perforation subsequent to infection (12 eyes) followed by those due to immunologic causes (six eyes) and trauma (six eyes). Twenty-four full-thickness tectonic grafts, nine mushroom grafts, and nine lamellar patch grafts were performed. Anatomical success was achieved in 35 of 41 (85.4%) eyes. Visual acuity of 6/24 or better was obtained in 29 of 41 (70.73%) eyes. The mean of best-corrected visual acuity (expressed in decimal) improved from 0.2 +/- 0.26 to 0.34 +/- 0.26 at an average follow-up of 10.83 +/- 6.27 months. The major complications were peripheral anterior synechiae in four eyes (9.76%) and graft melting in five eyes (12.2%).

CONCLUSIONS

Tectonic graft is a useful therapeutic option in selected cases of corneal thinning and perforations because it effectively restores the integrity of the eye and allows acceptable visual rehabilitation.

摘要

目的

评估在角膜变薄和穿孔病例中结构性移植的成功率。

方法

我们对40例患者的41只眼进行了42次结构性移植。在我们的治疗方案中使用了三种类型的结构性移植。它们分别是:(a)全层移植,(b)蘑菇状移植,以及(c)板层移植。评估的参数包括适应证、视力、移植部位、移植片的大小和类型、术后结果以及并发症(如有)。

结果

结构性移植最常见的适应证是感染后角膜变薄和穿孔(12只眼),其次是免疫性原因导致的(6只眼)和外伤导致的(6只眼)。进行了24次全层结构性移植、9次蘑菇状移植和9次板层补片移植。41只眼中有35只(85.4%)获得了解剖学成功。41只眼中有29只(70.73%)视力达到6/24或更好。在平均随访10.83±6.27个月时,最佳矫正视力(以小数表示)的平均值从0.2±0.26提高到了0.34±0.26。主要并发症是4只眼(9.76%)出现周边前粘连,5只眼(12.2%)出现移植片溶解。

结论

对于选定的角膜变薄和穿孔病例,结构性移植是一种有用的治疗选择,因为它能有效恢复眼球的完整性并实现可接受的视力康复。

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