Ramanan A V, Feldman B M
Division of Rheumatology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Curr Opin Rheumatol. 2002 Nov;14(6):658-62. doi: 10.1097/00002281-200211000-00005.
Juvenile dermatomyositis is a chronic inflammatory illness of unknown etiology that affects primarily muscle and skin. It has an incidence of 2-3 per 1,000,000, per year. The disease can affect other organ systems, including the gastrointestinal tract, lungs, and heart. In addition, calcinosis is seen in one-third of patients. The mainstay of therapy is corticosteroids; some children require additional immunosuppressive agents because of corticosteroid resistance or intolerance. Functional outcomes have become good with modern treatments, but the disease remains chronic in a large number of children and sequelae are often seen.
幼年皮肌炎是一种病因不明的慢性炎症性疾病，主要影响肌肉和皮肤。其年发病率为每100万人中有2 - 3例。该疾病可影响其他器官系统，包括胃肠道、肺和心脏。此外，三分之一的患者会出现钙质沉着。治疗的主要手段是使用皮质类固醇；一些儿童由于对皮质类固醇耐药或不耐受，需要额外的免疫抑制剂。随着现代治疗方法的应用，功能预后已有所改善，但在大量儿童中该疾病仍为慢性，且常出现后遗症。
