Holmes M V, Ioannou Y, Borysiewicz C, Sen D
Department of Adolescent Rheumatology, Centre for Rheumatology, University College London Hospital, 3rd Floor Central, 250 Euston Road, London NW1 2PQ, UK.
Clin Rheumatol. 2008 Jun;27 Suppl 1:S3-5. doi: 10.1007/s10067-007-0795-7. Epub 2007 Dec 21.
Juvenile dermatomyositis (JDM) is a rare disease, and Sjögren's syndrome (SS) is unusual in adolescents. We report the first case of biopsy-proven JDM and SS with pulmonary involvement. A 15-year-old adolescent boy presented with recurrent parotid gland hypertrophy, severe muscle weakness, pronounced skin rash and widespread lymphadenopathy. JDM was diagnosed by clinical examination, elevated muscle enzymes, electromyography and muscle biopsy; SS was diagnosed by xerostomia, anti-Ro (SS-A) positivity and histopathological analysis of salivary gland tissue. This case illustrates a systematic approach which we feel is especially important in the younger patient with a more plastic immune system.
青少年皮肌炎（JDM）是一种罕见疾病，而干燥综合征（SS）在青少年中并不常见。我们报告首例经活检证实的伴有肺部受累的青少年皮肌炎和干燥综合征病例。一名15岁青少年男性出现反复腮腺肿大、严重肌无力、明显皮疹和广泛淋巴结病。通过临床检查、肌酶升高、肌电图和肌肉活检诊断为青少年皮肌炎；通过口干、抗Ro（SS-A）阳性和唾液腺组织的组织病理学分析诊断为干燥综合征。本病例说明了一种系统的方法，我们认为这种方法对于免疫系统更具可塑性的年轻患者尤为重要。
