Jimenez Sergio A, Christner Paul J
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Curr Opin Rheumatol. 2002 Nov;14(6):671-80. doi: 10.1097/00002281-200211000-00008.
Animal models of systemic connective tissue diseases have provided valuable insights into the causative mechanisms and the pathogenesis of these diseases, and have provided the means to test potentially useful therapeutic interventions. Although numerous animal models for systemic sclerosis (SSc) have been described, the most extensively studied are murine. One advantage of murine animal models is the large body of genetic information available for the mouse that is not available for other species. No animal model described to date reproduces precisely all manifestations of SSc. However, all animal models display tissue fibrotic changes similar to those present in SSc. The prudent interpretation of the results obtained from the study of animal models has provided substantial and valuable information about the pathogenesis of the human disease.
系统性结缔组织疾病的动物模型为深入了解这些疾病的致病机制和发病机制提供了有价值的见解，也为测试潜在有效的治疗干预措施提供了手段。尽管已经描述了许多系统性硬化症（SSc）的动物模型，但研究最广泛的是小鼠模型。小鼠动物模型的一个优点是有大量关于小鼠的遗传信息，而其他物种则没有。迄今为止描述的任何动物模型都不能精确再现SSc的所有表现。然而，所有动物模型都显示出与SSc中相似的组织纤维化变化。对动物模型研究结果的审慎解读为人类疾病的发病机制提供了大量有价值的信息。
