Mukherjee Pulok K, Saritha G S, Suresh B
JSS College of Pharmacy, Rocklands, Post Box 20, Ootacamund - 643001, Tamil Nadu, India.
Phytother Res. 2002 Nov;16(7):692-5. doi: 10.1002/ptr.1016.
The antimicrobial activity of extracts of the leaves and stems of two different varieties of Hypericum was evaluated by the disc diffusion method. Petroleum ether, acetone, chloroform and methanol extracts of Hypericum mysorense and Hypericum patulum stems and leaves were investigated for their antimicrobial activity against six different strains of bacteria and fungi by the zone of inhibition method (ZIM). The results showed that both the stem and leaf extracts of both species have a very broad spectrum of antibacterial activity. The petroleum ether and acetone extract of the leaves and stems of H. mysorense did not show antifungal effects against any of the six fungal organisms tested but other extracts showed a potential antifungal effect which was comparable to that of griseofulvin, the standard antifungal agent. Thus these results demonstrate that the leaf and stem extracts of both the Hypericum species have a very broad spectrum of activity and suggest that they may be useful in the treatment of various microbial infections.
采用纸片扩散法对两种不同金丝桃属植物的叶和茎提取物的抗菌活性进行了评估。通过抑菌圈法（ZIM）研究了贯叶连翘和金丝梅茎和叶的石油醚、丙酮、氯仿和甲醇提取物对六种不同细菌和真菌菌株的抗菌活性。结果表明，这两个物种的茎和叶提取物均具有非常广泛的抗菌活性谱。贯叶连翘叶和茎的石油醚和丙酮提取物对所测试的六种真菌均未表现出抗真菌作用，但其他提取物表现出与标准抗真菌剂灰黄霉素相当的潜在抗真菌作用。因此，这些结果表明，两种金丝桃属植物的叶和茎提取物均具有非常广泛的活性谱，并表明它们可能对治疗各种微生物感染有用。
