Volianitis S, Secher N H
Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, Denmark.
J Physiol. 2002 Nov 1;544(3):977-84. doi: 10.1113/jphysiol.2002.023556.
The cardiovascular response to exercise with several groups of skeletal muscle suggests that work with the arms may decrease leg blood flow. This study evaluated whether intense exercise with the legs would have a similar effect on arm blood flow (Y(arm)) and O(2) consumption (V(O(2))(,arm)). Ten healthy male subjects (age 21 +/- 1 year; mean +/- S.D.) performed arm cranking at 80 % of maximum arm work capacity (A trial) and combined arm cranking with cycling at 60 % of maximum leg work capacity (A + L trial). The combined trial was a maximum effort for 5-6 min. Y(arm) measurement by thermodilution in the axilliary vein and arterial and venous blood samples permitted calculation of V(O(2))(,arm). During the combined trial, Y(arm) was reduced by 0.58 +/- 0.25 l min(-1) (19.1 +/- 3.0 %, P < 0.05) from the value during arm cranking (3.00 +/- 0.46 l min(-1)). The arterio-venous O(2) difference increased from 122 +/- 15 ml l(-1) during the arm trial to 150 +/- 21 ml l(-1) (P < 0.05) during the combined trial. Thus, V(O(2))(,arm) (0.45 +/- 0.06 l min(-1)) was reduced by 9.6 +/- 6.3 % (P < 0.05) and arm vascular conductance from 27 +/- 4 to 23 +/- 3 ml min(-1) (mmHg)(-1) (P < 0.05) as noradrenaline spillover from the arm increased from 7.5 +/- 3.5 to 13.8 +/- 4.2 nmol min(-1) (P < 0.05). The data suggest that during maximal whole body exercise in humans, arm vasoconstriction is established to an extent that affects oxygen delivery to and utilisation by working skeletal muscles.
几组骨骼肌运动时的心血管反应表明，上肢运动可能会减少腿部血流量。本研究评估了高强度腿部运动是否会对上肢血流量（Y(arm)）和耗氧量（V(O2)(,arm)）产生类似影响。10名健康男性受试者（年龄21±1岁；平均值±标准差）以最大上肢工作能力的80%进行上肢曲柄运动（A试验），并将上肢曲柄运动与以最大腿部工作能力的60%进行的骑行相结合（A+L试验）。联合试验为最大努力运动5 - 6分钟。通过热稀释法测量腋静脉中的Y(arm)以及动脉和静脉血样，可计算出V(O2)(,arm)。在联合试验期间，Y(arm)较上肢曲柄运动期间的值（3.00±0.46 l min(-1)）降低了0.58±0.25 l min(-1)（19.1±3.0%，P<0.05）。动静脉氧差从手臂试验期间的122±15 ml l(-1)增加到联合试验期间的150±21 ml l(-1)（P<0.05）。因此，V(O2)(,arm)（0.45±0.06 l min(-1)）降低了9.6±6.3%（P<0.05），上肢血管传导率从27±4降至23±3 ml min(-1) (mmHg)(-1)（P<0.05），同时上肢去甲肾上腺素溢出量从7.5±3.5增加到13.8±4.2 nmol min(-1)（P<0.05）。数据表明，在人类进行最大强度全身运动期间，上肢血管收缩达到了影响工作骨骼肌的氧气输送和利用的程度。
