Kadrmas Dan J, Christian Paul E
Medical Imaging Research Laboratory, Department of Radiology, University of Utah, Salt City 84108, USA.
J Nucl Med. 2002 Nov;43(11):1545-54.
The lesion detectability performance of 6 PET imaging platforms has been compared using a highly reproducible whole-body phantom and localization receiver operating characteristic (LROC) analysis.
A realistic whole-body phantom consisting of brain, thorax with lungs and liver, and pelvis with bladder was assembled and outfitted with 27 semipermanent (22)Na lesions of various sizes and activity concentrations. The background compartments were reproducibly filled with (18)F solutions. The phantom was imaged under the condition of equal emission scan time on 7 PET platforms: Advance, HR+, HR961, C-PET, IRIX, MCD, and AXIS. Imaging data were processed using manufacturer-supplied software and defaults, and LROC evaluation was performed using 11 human observers.
Near-nominal counting rates were obtained for the NaI systems, and the bismuth germanate (BGO) systems were operated well below nominal counting rates. The BGO systems provided the highest lesion detection performance, followed by the large-area dedicated NaI system, and hybrid PET gamma cameras. Lesion detectability was highly dependent on lesion size, with all systems exhibiting similar performance for 16-mm lesions but differentiated performance for lesions < or =12 mm.
Reconstruction methodology can have a significant effect on lesion detectability. PET lesion detectability performance is correlated with system cost and imaging characteristics. For a particular imaging task, care should be taken to ensure that the scanner being used is appropriate and that the scan time is adjusted accordingly to ensure good lesion detectability.
使用高度可重复的全身模型和定位接收器操作特性（LROC）分析，比较了6个PET成像平台的病变检测性能。
组装了一个逼真的全身模型，包括大脑、带有肺和肝脏的胸部以及带有膀胱的骨盆，并配备了27个大小和活度浓度各异的半永久性（22）钠病变。背景隔室用（18）氟溶液可重复填充。该模型在7个PET平台上进行了等发射扫描时间条件下的成像：Advance、HR+、HR961、C-PET、IRIX、MCD和AXIS。使用制造商提供的软件和默认设置处理成像数据，并由11名人类观察者进行LROC评估。
碘化钠（NaI）系统获得了接近标称计数率，锗酸铋（BGO）系统的运行计数率远低于标称计数率。BGO系统提供了最高的病变检测性能，其次是大面积专用NaI系统和混合型PET伽马相机。病变检测能力高度依赖于病变大小，所有系统对16毫米病变表现出相似的性能，但对小于或等于12毫米的病变表现出不同的性能。
重建方法对病变检测能力可能有显著影响。PET病变检测性能与系统成本和成像特性相关。对于特定的成像任务，应注意确保所使用的扫描仪合适，并相应调整扫描时间以确保良好的病变检测能力。
