Schichman Steven A, Lin Pei, Gilbrech Lori J, Gray Pamela S, Wilson Carla S, Sawyer Jeffrey R
Pathology and Laboratory Medicine Service, Central Arkansas Veterans Healthcare System, Little Rock 72205, USA.
J Mol Diagn. 2002 Nov;4(4):230-2. doi: 10.1016/S1525-1578(10)60708-8.
Short tandem repeats (STRs) are highly polymorphic DNA sequences in the human genome. STR genotype analysis is used for human identity testing and to monitor bone marrow engraftment after allogeneic transplantation. Engraftment analysis requires one or more informative STR loci that distinguish recipient from donor. The following case illustrates that chromosome loss in tumor cells during the course of disease may cause corresponding loss of an STR locus. This circumstance is a potential source of error in the interpretation of engraftment analysis, especially if only one informative allele is used to monitor engraftment.
短串联重复序列（STRs）是人类基因组中高度多态性的DNA序列。STR基因型分析用于人类身份鉴定以及监测异基因移植后的骨髓植入情况。植入分析需要一个或多个能区分受体和供体的信息性STR位点。以下案例表明，疾病过程中肿瘤细胞的染色体丢失可能导致相应STR位点的丢失。这种情况是植入分析解释中潜在的误差来源，尤其是在仅使用一个信息性等位基因来监测植入情况时。
