[变应性鼻炎下鼻甲黏膜中细胞间黏附分子的表达及其意义]
[The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance].
作者信息
Song Xieyi, Xiao Bijun, Ni Canrong, Zhao Shuwei, Ling Shunzhang
机构信息
Department of Otolaryngology, Affiliated Changzheng Hospital, Second Military Medical University, Shanghai 200003.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Aug;16(8):387-9.
OBJECTIVE
To study the expression of intercellular adhesion molecules in turbinate mucosa of allergic rhinitis and its significance.
METHOD
Samples of turbinate mucosa were from 20 cases of chronic hypertrophic rhinitis, 24 cases of non provocation period allergic rhinitis and 20 cases of provocation period allergic rhinitis and their paraffin sections were studied with immunohistochemical technique staining with ICAM 1 and LFA 1 monoclone antibodies.
RESULT
Expression of ICAM 1 and LFA 1 were higher in turbinate mucosa of provocation period allergic rhinitis than in chronic hypertrophic rhinitis and non provocation period allergic rhinitis turbinate mucosa(P < 0.01).
CONCLUSION
High expression of ICAM 1 and LFA 1 in turbinate mucosa of allergic rhinitis shows that the interaction of ICAM-1/LFA-1 may participate in the inflammatory reaction of allergic rhinitis and may play an important role in the pathogenesis and development of allergic rhinitis.
目的
研究细胞间黏附分子在变应性鼻炎鼻甲黏膜中的表达及其意义。
方法
取20例慢性肥厚性鼻炎、24例非发作期变应性鼻炎及20例发作期变应性鼻炎的鼻甲黏膜样本，制作石蜡切片，采用免疫组化技术，用细胞间黏附分子-1（ICAM-1）和淋巴细胞功能相关抗原-1（LFA-1）单克隆抗体进行染色。
结果
发作期变应性鼻炎鼻甲黏膜中ICAM-1和LFA-1的表达高于慢性肥厚性鼻炎及非发作期变应性鼻炎的鼻甲黏膜（P<0.01）。
结论
变应性鼻炎鼻甲黏膜中ICAM-1和LFA-1的高表达表明，ICAM-1/LFA-1相互作用可能参与变应性鼻炎的炎症反应，在变应性鼻炎的发病机制及发展过程中可能起重要作用。
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