Liu Zheng, Lu Xiang, Wang Heng, Peng Liyan, You Xuejun
Department of Otolaryngology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Jul;20(14):625-7.
To explore the protein expression of transforming growth factor (TGF)-beta1, interleukin (IL)-6, 11, and 17 in the nasal mucosa of allergic rhinitis patients.
The protein expression of TGF-beta1, IL-6, 11, and 17 in the inferior turbinate tissues from 19 allergic rhinitis patients and from 21 non-allergic patients underwent nasal septum operation was detected by enzyme-linked immunosorbent assay.
(1) Compared with tissues from non-allergic patients, the expression of TGF-beta1 protein was significant increased in the tissues from allergic rhinitis patients (P < 0.01); (2) As to the protein expression of IL-6, 11 and 17, there was no significant difference between allergic rhinitis patients and non-allergic patients (P > 0.05); (3) The expression of TGF-beta1, IL-6, 11, and 17 was similar between the allergic rhinitis patients with and without asthma (P > 0.05).
TGF-beta1 , while not IL-6, 11 and 17, may play a role in the tissue remodeling processes in allergic rhinitis. This expression profile may contribute to the difference in the tissue remodeling between allergic rhinitis and asthma.
探讨变应性鼻炎患者鼻黏膜中转化生长因子（TGF）-β1、白细胞介素（IL）-6、11及17的蛋白表达情况。
采用酶联免疫吸附测定法检测19例变应性鼻炎患者下鼻甲组织及21例接受鼻中隔手术的非变应性患者下鼻甲组织中TGF-β1、IL-6、11及17的蛋白表达。
（1）与非变应性患者组织相比，变应性鼻炎患者组织中TGF-β1蛋白表达显著增加（P < 0.01）；（2）IL-6、11及17的蛋白表达在变应性鼻炎患者与非变应性患者之间无显著差异（P > 0.05）；（3）有哮喘和无哮喘的变应性鼻炎患者中TGF-β1、IL-6、11及17的表达相似（P > 0.05）。
TGF-β1可能在变应性鼻炎的组织重塑过程中发挥作用，而IL-6、11及17则不然。这种表达谱可能导致变应性鼻炎与哮喘在组织重塑方面存在差异。
