Oliver J J, Kelly C, Jarvie D, Denieul S, Bateman D N
Scottish Poisons Information Bureau, NPIS Edinburgh, Royal Infirmary, UK.
Hum Exp Toxicol. 2002 Aug;21(8):463-6. doi: 10.1191/0960327102ht274cr.
Newer anti-depressants are often considered to be safer than more established anti-depressants. However, clinical experience of the effects of these agents in overdose is limited. Here, we present two cases of venlafaxine overdose that were complicated by a delayed rise in plasma creatine kinase. Although the clinical consequences were not serious, physicians should be alerted to the possibility of delayed rhabdomyolysis or serotonin syndrome in patients who have taken venlafaxine in overdose.
新型抗抑郁药通常被认为比老牌抗抑郁药更安全。然而，这些药物过量服用时效果的临床经验有限。在此，我们报告两例文拉法辛过量服用的病例，其并发血浆肌酸激酶延迟升高。尽管临床后果并不严重，但医生应警惕过量服用文拉法辛的患者出现延迟性横纹肌溶解或血清素综合征的可能性。
