Hinterhuber H, Lochenegg L
Arch Psychiatr Nervenkr (1970). 1975 Dec 22;220(4):335-45. doi: 10.1007/BF00342063.
According to the hypothesis of a biochemical disorder, we found that schizophrenic patients show a modified reaction to stress. We have checked 668 male schizophrenic patients and found 18 ulcers (2.69%) this is contrasted by the average incidence of ulcers at the rate of 10%.12 of the 18 probands had preliminary serious somatic lesions. We came to the conslusion that the hypothalamic stress response is altered: Schizophrenic patients and the normal population show a significant difference to the incidence of gastric ulcers.
根据生化紊乱假说,我们发现精神分裂症患者对应激的反应有所改变。我们检查了668名男性精神分裂症患者,发现18例溃疡(2.69%),而溃疡的平均发病率为10%。这18名先证者中有12人有初步的严重躯体病变。我们得出结论,下丘脑应激反应发生了改变:精神分裂症患者与正常人群在胃溃疡发病率上存在显著差异。