Gonzalez Raul, Carey Catherine, Grant Igor
Department of Psychiatry, Center for Medicinal Cannabis Research, University of California, San Diego 92103, USA.
J Clin Pharmacol. 2002 Nov;42(S1):48S-57S. doi: 10.1002/j.1552-4604.2002.tb06003.x.
Because there is a possibility that cannabis or cannabis-like molecules might be used as treatments for certain conditions in the future, it becomes important to consider the possible adverse effects of these compounds. In this paper, the authors review the evidence for persisting effects of nonacute cannabis use on the central nervous system, as reflected by alteration in neuropsychological performance. From the 40 articles that met criteria for inclusion in this review, the authors could not detect consistent evidence for persisting neuropsychological deficits in cannabis users; however, 22 of the 40 studies reported at least some subtle impairments. The inability to reach a firm conclusion results largely from methodological limitations inherent in most studies. These are considered in detail to inform future studies on (nonacute) consequences of cannabis consumption on cognitive abilities.
由于未来大麻或类似大麻的分子有可能被用于治疗某些病症，因此考虑这些化合物可能产生的不良反应就变得很重要。在本文中，作者回顾了非急性使用大麻对中枢神经系统持续影响的证据，这一点通过神经心理表现的改变得以体现。从符合本综述纳入标准的40篇文章中，作者未能发现大麻使用者存在持续神经心理缺陷的一致证据；然而，40项研究中的22项报告了至少一些细微的损伤。无法得出确切结论主要是由于大多数研究所固有的方法学局限性。本文将详细讨论这些局限性，以为未来关于大麻消费对认知能力（非急性）影响的研究提供参考。
