Saijo Nagahiro
Medical Oncology Division, National Cancer Center, Tokyo.
Intern Med. 2002 Oct;41(10):770-3. doi: 10.2169/internalmedicine.41.770.
Recent progress in molecular biology has led to the identification of numerous molecular targets of cancer chemotherapy, and the strategies for new drug discovery have concentrated on target-based screening. In the development of target-based drugs, translational research is considered to be essential. In this review, the definition of translational research is clearly explained, and the points of misunderstanding of Japanese researchers are discussed and resolved. The primary goal of translational research is to integrate the advanced informations of molecular biology in moving forward from phase I and II trials to phase III trials of target-based drugs.
分子生物学的最新进展已促成众多癌症化疗分子靶点的识别，新药研发策略也集中于基于靶点的筛选。在基于靶点的药物研发中，转化研究被认为至关重要。在本综述中，明确解释了转化研究的定义，并讨论和解决了日本研究人员的误解点。转化研究的主要目标是在基于靶点的药物从I期和II期试验推进到III期试验的过程中整合分子生物学的前沿信息。
