Hegyi Péter, Petersen Ole H, Holgate Stephen, Erőss Bálint, Garami András, Szakács Zsolt, Dobszai Dalma, Balaskó Márta, Kemény Lajos, Peng Shuang, Monteiro Joao, Varró András, Lamont Tara, Laurence Jeffrey, Gray Zoe, Pickles Andrew, FitzGerald Garret A, Griffiths Christopher E M, Jassem Jacek, Rusakov Dmitri A, Verkhratsky Alexei, Szentesi Andrea
Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK.
J Clin Med. 2020 May 19;9(5):1532. doi: 10.3390/jcm9051532.
Translational science has gained prominence in medicine, but there is still much work to be done before scientific results are used optimally and incorporated into everyday health practice. As the main focus is still on generating new scientific data with financial resources primarily available for that purpose, other activities that are necessary in the transition from research to community benefit are considered less needy. The European Statistical Office of the European Commission has recently reported that 1.7 million people under 75 years of age died in Europe in 2016, with around 1.2 million of those deaths being avoidable through effective primary prevention and public health intervention. Therefore, Academia Europaea, one of the five Pan-European networks that form SAPEA (Science Advice for Policy by European Academies), a key element of the European Commission's Scientific Advice Mechanism (SAM), has launched a project to develop a model to facilitate and accelerate the utilisation of scientific knowledge for public and community benefit.
During the process, leaders in the field, including prominent basic and clinical researchers, editors-in-chief of high-impact journals publishing translational research articles, translational medicine (TM) centre leaders, media representatives, academics and university leaders, developed the TM cycle, a new model that we believe could significantly advance the development of TM.
This model focuses equally on the acquisition of new scientific results healthcare, understandable and digestible summation of results, and their communication to all participants. We have also renewed the definition in TM, identified challenges and recommended solutions.
The authors, including senior officers of Academia Europaea, produced this document to serve as a basis for revising thinking on TM with the end result of enabling more efficient and cost-effective healthcare.
转化科学在医学领域已日益重要，但在科学成果得到最佳利用并融入日常医疗实践之前，仍有许多工作要做。由于主要重点仍在于生成新的科学数据，且财政资源主要用于此目的，因此从研究向社区受益转化过程中所需的其他活动被认为需求较少。欧盟委员会欧洲统计局最近报告称，2016年欧洲有170万75岁以下的人死亡，其中约120万例死亡可通过有效的一级预防和公共卫生干预避免。因此，欧洲科学院作为构成欧洲科学院为政策提供科学建议（SAPEA）的五个泛欧网络之一，也是欧盟委员会科学建议机制（SAM）的关键要素，发起了一个项目，以开发一个模型，促进和加速科学知识用于公共和社区利益。
在此过程中，该领域的领导者，包括杰出的基础和临床研究人员、发表转化研究文章的高影响力期刊的主编、转化医学（TM）中心负责人、媒体代表、学者和大学领导，开发了TM循环，这是一个我们认为可以显著推进转化医学发展的新模型。
该模型同样关注新科学成果的获取、医疗保健领域对成果的易懂且可消化的总结以及向所有参与者的传播。我们还更新了转化医学的定义，确定了挑战并提出了建议解决方案。
包括欧洲科学院高级官员在内的作者撰写本文件，作为修订转化医学思维的基础，最终实现更高效且具成本效益的医疗保健。
