Ota Kikuko, Suehiro Tadashi, Ikeda Yukio, Arii Kaoru, Kumon Yoshitaka, Hashimoto Kozo
Second Department of Internal Medicine, Kochi Medical School.
Intern Med. 2002 Oct;41(10):842-7. doi: 10.2169/internalmedicine.41.842.
We report a case of Klinefelter's syndrome in a 48-year-old man who had diabetes mellitus associated with severe insulin resistance. We diagnosed him with Klinefelter's syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomal aberration of 47,XXY. He showed severe decreased insulin sensitivity in a hyper-insulinemic euglycemic clamp test. He had injected over 100 units of insulin per day, however, testosterone replacement and administration of pioglitazone improved his glycemic control, which resulted in a decrease of insulin dose to less than 50 units per day. Here, we discuss the characteristics of diabetes mellitus associated with Klinefelter's syndrome in Japanese patients including this case.
我们报告一例48岁男性克氏综合征患者，其患有与严重胰岛素抵抗相关的糖尿病。根据其萎缩的睾丸、激素检查中的原发性性腺功能减退以及47,XXY的染色体畸变，我们诊断他患有克氏综合征。在高胰岛素正常血糖钳夹试验中，他表现出严重的胰岛素敏感性降低。他每天注射超过100单位的胰岛素，然而，睾酮替代治疗和吡格列酮的使用改善了他的血糖控制，使胰岛素剂量减少至每天少于50单位。在此，我们讨论包括该病例在内的日本患者中与克氏综合征相关的糖尿病特征。
