Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, and Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100730, China.
Chin Med J (Engl). 2012 Mar;125(5):937-40.
Klinefelter’s syndrome (KS) is the most common sex chromosome disease in men. Classical features of the syndrome include a eunuchoidal body habitus, small testes and hypergonadotrophic hypogonadism. There has been an increased risk of diabetes mellitus and autoimmune disease for KS patients. This paper reports a case of KS in association with type 1 diabetes mellitus. The patient was a 21-year-old man, who has been confirmed by absolute insulin deficiency and positive IA-2 autoantibody. The hyperinsulinemic euglycemic clamp test indicated his insulin sensitivity in normal range, and his blood glucose was controlled well by the insulin therapy.
克莱恩费尔特综合征（KS）是男性最常见的性染色体疾病。该综合征的典型特征包括宦官体型、小睾丸和促性腺激素性性腺功能减退症。KS 患者的糖尿病和自身免疫性疾病风险增加。本文报告了一例 KS 合并 1 型糖尿病。患者为 21 岁男性，经绝对胰岛素缺乏和 IA-2 自身抗体阳性确诊。高胰岛素-正常血糖钳夹试验表明其胰岛素敏感性正常，胰岛素治疗可良好控制血糖。
