Nash David R, Harman Jeffrey, Wald Ellen R, Kelleher Kelly J
Department of Pediatrics, University of Pittsburgh School of Medicine, PA 15213, USA.
Arch Pediatr Adolesc Med. 2002 Nov;156(11):1114-9. doi: 10.1001/archpedi.156.11.1114.
To determine if the rate of appropriate antibiotic use in the treatment of children with bronchitis, viral upper respiratory tract infections, sinusitis, otitis media, and pharyngitis has changed in recent years and to identify factors that are associated with the use of inappropriate antibiotic therapy.
The National Ambulatory Medical Care Survey was used to examine the antimicrobial prescribing habits of physicians who provide primary care for children. Data were analyzed from 1995-1998.
Office-based physician practices.
Pediatricians, family physicians, and generalists completing survey forms for patients younger than 18 years.
The appropriate use of antibiotics for upper respiratory tract infections.
Multivariate analyses were used to examine factors associated with the use of inappropriate antibiotics to treat either upper respiratory tract infections or bronchitis. Patients seen in 1998 and diagnosed as having upper respiratory tract infections were 0.69 (95% confidence interval, 0.59-0.81) times less likely to be treated with antibiotics compared with patients seen in 1995. Multivariate analyses were also used to assess factors associated with the use of antibiotics with a suboptimal therapeutic profile for the treatment of either sinusitis or otitis media. Children diagnosed as having either sinusitis or otitis media were 0.3 (95% confidence interval [CI], 0.16-0.48) times less likely to receive antibiotics with a suboptimal therapeutic effect in 1998 compared with 1995.
Physicians are slowly improving their antibiotic prescribing patterns but the use of inappropriate antibiotics is still common. Almost half of patients with upper respiratory tract infections receive antibiotics.
确定近年来在治疗支气管炎、病毒性上呼吸道感染、鼻窦炎、中耳炎和咽炎患儿时,恰当使用抗生素的比例是否发生变化,并找出与不当抗生素治疗使用相关的因素。
采用国家门诊医疗护理调查来检查为儿童提供初级护理的医生的抗菌药物处方习惯。分析了1995年至1998年的数据。
基于办公室的医生诊疗实践。
为18岁以下患者填写调查问卷的儿科医生、家庭医生和全科医生。
上呼吸道感染抗生素的恰当使用情况。
采用多变量分析来检查与使用不当抗生素治疗上呼吸道感染或支气管炎相关的因素。与1995年就诊的患者相比,1998年被诊断为上呼吸道感染的患者接受抗生素治疗的可能性降低了0.69倍(95%置信区间,0.59 - 0.81)。多变量分析还用于评估与使用治疗效果欠佳的抗生素治疗鼻窦炎或中耳炎相关的因素。与1995年相比,1998年被诊断为患有鼻窦炎或中耳炎的儿童接受治疗效果欠佳的抗生素的可能性降低了0.3倍(95%置信区间[CI],0.16 - 0.48)。
医生的抗生素处方模式正在缓慢改善,但不当抗生素的使用仍然很普遍。几乎一半的上呼吸道感染患者接受了抗生素治疗。