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为患感冒、上呼吸道感染和支气管炎的儿童开具抗生素处方。

Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis.

作者信息

Nyquist A C, Gonzales R, Steiner J F, Sande M A

机构信息

Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA.

出版信息

JAMA. 1998 Mar 18;279(11):875-7. doi: 10.1001/jama.279.11.875.

Abstract

CONTEXT

The spread of antibiotic-resistant bacteria is associated with antibiotic use. Children receive a significant proportion of the antibiotics prescribed each year and represent an important target group for efforts aimed at reducing unnecessary antibiotic use.

OBJECTIVE

To evaluate antibiotic-prescribing practices for children younger than 18 years who had received a diagnosis of cold, upper respiratory tract infection (URI), or bronchitis in the United States.

DESIGN

Representative national survey of practicing physicians participating in the National Ambulatory Medical Care Survey conducted in 1992 with a response rate of 73%.

SETTING

Office-based physician practices.

PARTICIPANTS

Physicians completing patient record forms for patients younger than 18 years.

MAIN OUTCOME MEASURES

Principal diagnoses and antibiotic prescriptions.

RESULTS

A total of 531 pediatric office visits were recorded that included a principal diagnosis of cold, URI, or bronchitis. Antibiotics were prescribed to 44% of patients with common colds, 46% with URIs, and 75% with bronchitis. Extrapolating to the United States, 6.5 million prescriptions (12% of all prescriptions for children) were written for children diagnosed as having a URI or nasopharyngitis (common cold), and 4.7 million (9% of all prescriptions for children) were written for children diagnosed as having bronchitis. After controlling for confounding factors, antibiotics were prescribed more often for children aged 5 to 11 years than for younger children (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.13-3.33) and rates were lower for pediatricians than for nonpediatricians (OR, 0.57; 95% CI, 0.35-0.92). Children aged 0 to 4 years received 53% of all antibiotic prescriptions, and otitis media was the most frequent diagnosis for which antibiotics were prescribed (30% of all prescriptions).

CONCLUSIONS

Antibiotic prescribing for children diagnosed as having colds, URIs, and bronchitis, conditions that typically do not benefit from antibiotics, represents a substantial proportion of total antibiotic prescriptions to children in the United States each year.

摘要

背景

抗生素耐药菌的传播与抗生素使用有关。儿童每年接受的抗生素处方占很大比例,是旨在减少不必要抗生素使用的努力的重要目标群体。

目的

评估美国18岁以下被诊断为感冒、上呼吸道感染(URI)或支气管炎的儿童的抗生素处方情况。

设计

1992年对参与国家门诊医疗调查的执业医师进行的代表性全国性调查,回复率为73%。

地点

基于办公室的医师诊疗。

参与者

为18岁以下患者填写病历表的医师。

主要观察指标

主要诊断和抗生素处方。

结果

共记录了531次儿科门诊就诊,主要诊断为感冒、URI或支气管炎。44%的普通感冒患者、46%的URI患者和75%的支气管炎患者接受了抗生素处方。推断到美国,为被诊断患有URI或鼻咽炎(普通感冒)的儿童开出了650万张处方(占儿童所有处方的12%),为被诊断患有支气管炎的儿童开出了470万张处方(占儿童所有处方的9%)。在控制混杂因素后,5至11岁儿童比年幼儿童更常接受抗生素处方(优势比[OR],1.94;95%置信区间[CI],1.13 - 3.33),儿科医生的处方率低于非儿科医生(OR,0.57;95%CI,0.35 - 0.92)。0至4岁儿童接受了所有抗生素处方的53%,中耳炎是最常开出抗生素处方的诊断(占所有处方的30%)。

结论

对于被诊断为感冒、URI和支气管炎的儿童(这些病症通常无法从抗生素中获益)开具的抗生素处方,占美国每年儿童抗生素处方总量的很大比例。

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