Hulka J F
Am J Obstet Gynecol. 1975 Jun 1;122(3):337-48. doi: 10.1016/0002-9378(75)90180-5.
This report reviews animal and human studies undertaken to develop simpler, safer, and more acceptable methods of female sterilization. Animal studies revealed inadequate prevention of pregnancy by tubocclusive methods from within the uterus, and the laparoscopic route was chosen. A series of clips were evaluated, and a clip was designed which would have a spring load, be wide enough to cause true tissue necrosis, have a firm grip on the tube to prevent dislodgement, and have a smooth external surface. Extensive human trials of the clip and applicator have resulted in over 1,000 patients with clips applied by 27 physicians in 10 centers throughout the world. Six pregnancies appear to have been due so far to application onto structures other than the isthmic portion of the tube. Complications due to the clip itself appear to be minimal, and the feasibility of performing this operation under local anesthesia in a hospital facility other than the operating room is currently under evaluation.
本报告回顾了为开发更简单、更安全且更易接受的女性绝育方法而进行的动物和人体研究。动物研究表明，子宫内闭塞法预防妊娠的效果不佳，因此选择了腹腔镜途径。对一系列夹子进行了评估，并设计了一种夹子，它具有弹簧负载，宽度足以导致真正的组织坏死，能牢固夹住输卵管以防止移位，且外表面光滑。对该夹子及施夹器进行了广泛的人体试验，全球10个中心的27位医生为1000多名患者施用了夹子。到目前为止，似乎有6例妊娠是由于夹子施用于输卵管峡部以外的结构所致。夹子本身引起的并发症似乎很少，目前正在评估在手术室以外的医院设施中进行局部麻醉下该手术的可行性。
