O'Leary Niall D, O'Connor Kevin E, Dobson Alan D W
Microbiology Department, National Food Biotechnology Centre, National University of Ireland, Cork, Ireland.
FEMS Microbiol Rev. 2002 Nov;26(4):403-17. doi: 10.1111/j.1574-6976.2002.tb00622.x.
The last few decades have seen a steady increase in the global production and utilisation of the alkenylbenzene, styrene. The compound is of major importance in the petrochemical and polymer-processing industries, which can contribute to the pollution of natural resources via the release of styrene-contaminated effluents and off-gases. This is a cause for some concern as human over-exposure to styrene, and/or its early catabolic intermediates, can have a range of destructive health effects. These features have prompted researchers to investigate routes of styrene degradation in microorganisms, given the potential application of these organisms in bioremediation/biodegradation strategies. This review aims to examine the recent advances which have been made in elucidating the underlying biochemistry, genetics and physiology of microbial styrene catabolism, identifying areas of interest for the future and highlighting the potential industrial importance of individual catabolic pathway enzymes.
在过去几十年中，全球链烯基苯（苯乙烯）的产量和利用率稳步增长。该化合物在石油化工和聚合物加工行业中至关重要，这些行业通过排放受苯乙烯污染的废水和废气可能导致自然资源污染。这引发了一些担忧，因为人类过度接触苯乙烯和/或其早期分解代谢中间体可能会产生一系列破坏性的健康影响。鉴于这些微生物在生物修复/生物降解策略中的潜在应用，这些特征促使研究人员研究微生物中苯乙烯的降解途径。本综述旨在研究在阐明微生物苯乙烯分解代谢的基础生物化学、遗传学和生理学方面取得的最新进展，确定未来感兴趣的领域，并强调单个分解代谢途径酶的潜在工业重要性。
