Kongkathip Ngampong, Dhumma-upakorn Prasan, Kongkathip Boonsong, Chawananoraset Khanittha, Sangchomkaeo Prapasri, Hatthakitpanichakul Som
Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand.
J Ethnopharmacol. 2002 Nov;83(1-2):95-9. doi: 10.1016/s0378-8741(02)00210-6.
This report describes the isolation of two triterpenes from the stems of Tinospora crispa, namely, cycloeucalenol (1). and cycloeucalenone (2). for the first time. It was found that cycloeucalenol (1). slightly increased the right atrial force of contraction whereas it showed an initial reduction followed by sustained reduction of about 10% on the left atria of the rat in vitro. Cycloeucalenone showed slight change from the control on the right and left atrial force. These results suggest that cycloeucalenol and cycloeucalenone produced mild cardiotonic effects.
本报告首次描述了从皱波青牛胆茎中分离出两种三萜类化合物，即环桉叶醇（1）和环桉叶酮（2）。研究发现，环桉叶醇（1）能轻微增加右心房的收缩力，而在体外对大鼠左心房则表现出先降低，随后持续降低约10%。环桉叶酮对右心房和左心房的收缩力与对照组相比变化不大。这些结果表明，环桉叶醇和环桉叶酮具有轻微的强心作用。
