Haque Ehfazul, Bari Md Sazzadul, Khandokar Labony, Anjum Juhaer, Jantan Ibrahim, Seidel Veronique, Haque Md Areeful
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455 USA.
Department of Chemistry, Purdue University, West Lafayette, IN 47907 USA.
Phytochem Rev. 2023;22(1):211-273. doi: 10.1007/s11101-022-09843-y. Epub 2022 Nov 3.
(L.) Hook. f. & Thomson (Menispermaceae) is a plant indigenous to Africa and South-East Asia. It is widely used in ethnomedicine to alleviate various diseases including hypertension, diabetes, rheumatism, jaundice, inflammation, fever, fractures, scabies, and urinary disorders. A total of 167 phytoconstituents, belonging to 12 different chemical categories, including alkaloids, flavonoids, terpenoids, and phenolic compounds have thus far been isolated from various parts of Numerous in vitro and in vivo investigations have already established the antidiabetic, anticancer, antiparasitic, antimicrobial, immunomodulatory, hepatoprotective, analgesic, antipyretic, antihyperuricemic, and pesticidal activity of this plant, as well as its effects on the cardiac and the central nervous system. Most pharmacological investigations to date have been carried out on plant extracts and fractions. The exact identity of the phytoconstituents responsible for the observed biological effects and their mode of action at the molecular level are yet to be ascertained. Toxicological studies have demonstrated that is relatively safe, although dose-dependent hepatotoxicity is a concern at high doses. This review presents a comprehensive update and analysis on studies related to the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of . It provides some critical insights into the current scientific knowledge on this plant and its future potential in pharmaceutical research.
（L.）胡克. f. & 汤姆森（防己科）是一种原产于非洲和东南亚的植物。它在民族医学中被广泛用于缓解各种疾病，包括高血压、糖尿病、风湿病、黄疸、炎症、发热、骨折、疥疮和泌尿系统疾病。迄今为止，已从该植物的各个部位分离出总共167种植物成分，属于12种不同的化学类别，包括生物碱、黄酮类化合物、萜类化合物和酚类化合物。众多的体外和体内研究已经证实了该植物的抗糖尿病、抗癌、抗寄生虫、抗菌、免疫调节、保肝、镇痛、解热、抗高尿酸血症和杀虫活性，以及其对心脏和中枢神经系统的影响。迄今为止，大多数药理学研究都是在植物提取物和馏分上进行的。导致观察到的生物学效应的植物成分的确切身份及其在分子水平上的作用方式尚待确定。毒理学研究表明，该植物相对安全，尽管高剂量时剂量依赖性肝毒性是一个问题。本综述对与该植物的民族药用、植物化学、药理活性和毒理学概况相关的研究进行了全面更新和分析。它对关于这种植物的当前科学知识及其在药物研究中的未来潜力提供了一些关键见解。
