Thomas Alex, Rajesh E K, Kumar D Suresh
CARe Keralam Ltd, KINFRA Small Industries Park, KINFRA Park P.O., Koratty, 680 309, Kerala, India.
My Holdings Consultancy Pvt Ltd, First Floor, Supriya Tower, Chalakudy, 680307, Thrissur District, Kerala, India.
Phytother Res. 2016 Mar;30(3):357-66. doi: 10.1002/ptr.5559. Epub 2016 Jan 7.
Tinospora crispa is a medicinal plant belonging to the botanical family Menispermiaceae. The plant is widely distributed in Southeast Asia and the northeastern region of India. A related species Tinospora cordifolia is used in Ayurveda for treating a large spectrum of diseases. Traditional healers of Thailand, Malaysia, Guyana, Bangladesh and the southern Indian province of Kerala use this plant in the treatment of diabetes. Many diterpenes, triterpenes, phytosteroids, alkaloids and their glycosides have been isolated from T. crispa. Cell culture and animal studies suggest that the herb stimulates secretion of insulin from β-cells. It also causes dose-dependent and time-dependent enhancement of glucose uptake in muscles. However, in view of the reported hepatotoxicity, this herb may be used with caution. This article reviews the animal studies and human clinical trials carried out using this herb. Areas of future research are also identified.
锡叶藤是一种属于防己科的药用植物。该植物广泛分布于东南亚和印度东北地区。一种相关物种心叶青牛胆在阿育吠陀医学中用于治疗多种疾病。泰国、马来西亚、圭亚那、孟加拉国以及印度南部喀拉拉邦的传统治疗师使用这种植物治疗糖尿病。从锡叶藤中已分离出许多二萜类、三萜类、植物甾醇类、生物碱及其糖苷。细胞培养和动物研究表明，这种草药可刺激β细胞分泌胰岛素。它还能使肌肉中的葡萄糖摄取呈剂量依赖性和时间依赖性增强。然而，鉴于已报道的肝毒性，使用这种草药时可能需谨慎。本文综述了使用这种草药进行的动物研究和人体临床试验。还确定了未来的研究领域。
