Yu Z F, Kong L D, Chen Y
Institute of Functional Biomolecule, School of Life Sciences, Nanjing University, Nanjing 210093, China.
J Ethnopharmacol. 2002 Nov;83(1-2):161-5. doi: 10.1016/s0378-8741(02)00211-8.
Curcuma longa (turmeric) is a well-known indigenous herbal medicine. The aqueous extracts, when administered orally to the mice from 140 to 560 mg/kg for 14 days, were able to elicit dose-dependent relation of immobility reduction in the tail suspension test and the forced swimming test in mice. The effects of the extracts at the dose of 560 mg/kg were more potent than that of reference antidepressant fluoxetine. The extracts, at the dose of 140 mg/kg or above for 14 days, significantly inhibited the monoamine oxidize A (MAO) activity in mouse whole brain at a dose-dependent manner, however, oral administration of the extract only at a dose of 560 mg/kg produced observable MAO B inhibitory activity in animal brain. Fluoxetine showed only a tendency to inhibit MAO A and B activity in animal brain in the study. Neither the extracts of C. longa nor fluoxetine, at the doses tested, produced significant effects on locomotor activity. These results demonstrated that C. longa had specifically antidepressant effects in vivo. The activity of C. longa in antidepression may mediated in part through MAO A inhibition in mouse brain.
姜黄是一种著名的本土草药。当以140至560毫克/千克的剂量口服给予小鼠14天时，其水提取物在小鼠的悬尾试验和强迫游泳试验中能够引发剂量依赖性的不动时间减少。560毫克/千克剂量的提取物的效果比参考抗抑郁药氟西汀更强。140毫克/千克及以上剂量的提取物连续14天以剂量依赖性方式显著抑制小鼠全脑中的单胺氧化酶A（MAO）活性，然而，仅560毫克/千克剂量的提取物口服给药才在动物脑中产生可观察到的MAO B抑制活性。在该研究中，氟西汀仅显示出抑制动物脑中MAO A和B活性的趋势。在所测试的剂量下，姜黄提取物和氟西汀对运动活性均未产生显著影响。这些结果表明姜黄在体内具有特异性抗抑郁作用。姜黄的抗抑郁活性可能部分通过抑制小鼠脑中的MAO A来介导。
