Mony Tamanna Jahan, Elahi Fazle, Choi Ji Woong, Park Se Jin
Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Korea.
Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea.
Antioxidants (Basel). 2022 Sep 18;11(9):1834. doi: 10.3390/antiox11091834.
Terpenoids are widely distributed in nature, especially in the plant kingdom, and exhibit diverse pharmacological activities. In recent years, screening has revealed a wide variety of new terpenoids that are active against different psychiatric disorders. This review synthesized the current published preclinical studies of terpenoid use in psychiatric disorders. This review was extensively investigated to provide empirical evidence regarding the neuropharmacological effects of the vast group of terpenoids in translational models of psychiatric disorders, their relevant mechanisms of action, and treatment regimens with evidence of the safety and psychotropic efficacy. Therefore, we utilized nine (9) electronic databases and performed manual searches of each. The relevant data were retrieved from the articles published until present. We used the search terms "terpenoids" or "terpenes" and "psychiatric disorders" ("psychiatric disorders" OR "psychiatric diseases" OR "neuropsychiatric disorders" OR "psychosis" OR "psychiatric symptoms"). The efficacy of terpenoids or biosynthetic compounds in the terpenoid group was demonstrated in preclinical animal studies. Ginsenosides, bacosides, oleanolic acid, asiatic acid, boswellic acid, mono- and diterpenes, and different forms of saponins and triterpenoids were found to be important bioactive compounds in several preclinical studies of psychosis. Taken together, the findings of the present review indicate that natural terpenoids and their derivatives could achieve remarkable success as an alternative therapeutic option for alleviating the core or associated behavioral features of psychiatric disorders.
萜类化合物在自然界中广泛分布，尤其是在植物界，并具有多种药理活性。近年来，筛选发现了多种对不同精神障碍具有活性的新型萜类化合物。本综述综合了目前已发表的关于萜类化合物用于精神障碍的临床前研究。本综述进行了广泛的调查，以提供有关大量萜类化合物在精神障碍转化模型中的神经药理学作用、其相关作用机制以及具有安全性和精神疗效证据的治疗方案的实证依据。因此，我们利用了9个电子数据库并对每个数据库进行了手动检索。相关数据从截至目前发表的文章中获取。我们使用的检索词为“萜类化合物”或“萜烯”以及“精神障碍”（“精神障碍”或“精神疾病”或“神经精神障碍”或“精神病”或“精神症状”）。萜类化合物或萜类化合物组中的生物合成化合物的疗效在临床前动物研究中得到了证实。在几项精神病临床前研究中，人参皂苷、积雪草苷、齐墩果酸、积雪草总苷、乳香酸、单萜和二萜以及不同形式的皂苷和三萜被发现是重要的生物活性化合物。综上所述，本综述的研究结果表明，天然萜类化合物及其衍生物作为缓解精神障碍核心或相关行为特征的替代治疗选择可能会取得显著成功。
