Bunge Silvia A, Hazeltine Eliot, Scanlon Michael D, Rosen Allyson C, Gabrieli J D E
Neurosciences Program, Stanford University, USA.
Neuroimage. 2002 Nov;17(3):1562-71. doi: 10.1006/nimg.2002.1252.
The ability to select between possible responses to a given situation is central to human cognition. The goal of this study was to distinguish between brain areas representing candidate responses and areas selecting between competing response alternatives. Event-related fMRI data were acquired while 10 healthy adults performed a task used to examine response competition: the Eriksen flanker task. Left parietal cortex was activated by either of two manipulations that increased the need to maintain a representation of possible responses. In contrast, lateral prefrontal and rostral anterior cingulate cortices were specifically engaged by the need to select among competing response alternatives. These findings support the idea that parietal cortex is involved in activating possible responses on the basis of learned stimulus-response associations, and that prefrontal cortex is recruited when there is a need to select between competing responses.
在给定情境下从可能的反应中进行选择的能力是人类认知的核心。本研究的目的是区分代表候选反应的脑区和在相互竞争的反应选项之间进行选择的脑区。在10名健康成年人执行一项用于检查反应竞争的任务（埃里克森侧翼任务）时，采集了事件相关功能磁共振成像数据。两种操作中的任何一种增加了维持可能反应表征的需求时，左顶叶皮层都会被激活。相比之下，外侧前额叶和喙前扣带回皮层则特别因在相互竞争的反应选项之间进行选择的需求而被激活。这些发现支持了这样一种观点，即顶叶皮层基于习得的刺激-反应关联参与激活可能的反应，而前额叶皮层则在需要在相互竞争的反应之间进行选择时被调用。
