Póvoa R, Cardoso S H, Luna Filho B, Ferreira Filho C, Ferreira M, Ferreira C
Escola Paulista de Medicina, UNIFESP, São Paulo.
Arq Bras Cardiol. 1997 May;68(5):377-80.
A man (46 years-old) was admitted to the intensive care unit (ICU) with a history that eight hours before he had voluntarily drank 100 ml of malathion. He complained of a burning pain on the anterior thorax and was confused. His cardiovascular evaluation was normal and his breathing was heavy with some rales on the pulmonary auscultation. He was treated with atropine and contrathion and rapidly evolved into coma. Electrocardiogram showed subendocardial lesion in the inferior wall with diffuse ly altered ventricular repolarization and increase QT interval. During the ICU period his cardiac enzyme levels also raised. The patient died in the 8th day after admission. The pathological evaluation of the heart revealed foci of myocardial necrosis. This is the 1st case of medical literature with histological confirmation of myocardial necrosis from organophosphate intoxication.
一名46岁男性因在入院前八小时自愿喝下100毫升马拉硫磷而被送入重症监护病房（ICU）。他主诉前胸有灼痛且意识模糊。其心血管评估正常，呼吸沉重，肺部听诊有一些啰音。他接受了阿托品和解磷定治疗，并迅速陷入昏迷。心电图显示下壁心内膜下病变，伴有弥漫性心室复极改变及QT间期延长。在ICU期间，他的心肌酶水平也升高了。患者在入院后第8天死亡。心脏的病理评估显示有心肌坏死灶。这是医学文献中首例经组织学证实由有机磷中毒导致心肌坏死的病例。
