莱姆病患者不同地理区域人群对狭义伯氏疏螺旋体P66可变表面环抗原的差异性免疫反应。
Differential immune response to the variable surface loop antigen of P66 of Borrelia burgdorferi sensu lato species in geographically diverse populations of lyme borreliosis patients.
作者信息
Ornstein Katharina, Ostberg Yngve, Bunikis Jonas, Noppa Laila, Berglund Johan, Norrby Ragnar, Bergström Sven
机构信息
Department of Medical Microbiology, Dermatology, and Infection, Lund University, Lund, Sweden.
出版信息
Clin Diagn Lab Immunol. 2002 Nov;9(6):1382-4. doi: 10.1128/cdli.9.6.1382-1384.2002.
Abstract
We have studied the immune response to a variable surface-exposed loop region of the P66 outer membrane protein from Borrelia burgdorferi sensu lato by using an enzyme immunoassay. Lyme borreliosis populations found in North America and Sweden were preferentially more seroreactive to P66 from their respective regional species, namely, B. burgdorferi sensu stricto and B. garinii and B. afzelii, respectively.
摘要
我们通过酶免疫测定法研究了针对伯氏疏螺旋体狭义种P66外膜蛋白可变表面暴露环区的免疫反应。在北美和瑞典发现的莱姆病螺旋体种群对来自各自区域物种（即狭义伯氏疏螺旋体、伽氏疏螺旋体和阿氏疏螺旋体）的P66优先表现出更高的血清反应性。
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