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人类血浆多巴胺β羟化酶活性的遗传学研究。

A genetic study of plasma dopamine beta hydroxylase activity in man.

作者信息

Mendlewicz J, Levitt M, Fleiss J L

出版信息

Acta Genet Med Gemellol (Roma). 1975;24(1-2):105-10. doi: 10.1017/s1120962300021946.

DOI:10.1017/s1120962300021946
PMID:1241486
Abstract

Plasma dopamine beta hydroxylase (DBH) activity was determined in MZ twins and in siblings of both sexes. The enzyme activities were found to be virtually identical in MZ twins. DBH activity was less similar in same-sex sibs, but still significantly correlated. These results indicate that plasma DBH activity is genetically determined.

摘要

测定了同卵双胞胎以及不同性别的兄弟姐妹的血浆多巴胺β羟化酶(DBH)活性。结果发现,同卵双胞胎的酶活性几乎完全相同。同性兄弟姐妹的DBH活性相似度较低,但仍存在显著相关性。这些结果表明,血浆DBH活性是由基因决定的。

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引用本文的文献

1
Plasma dopamine beta hydroxylase activity in affective disorders.情感障碍中的血浆多巴胺β羟化酶活性
Psychopharmacologia. 1976 Mar 16;46(2):205-10. doi: 10.1007/BF00421393.
2
A twin study on three enzymes (DBH, COMT, MAO) of catecholamine metabolism. Correlations with MMPI.
Psychopharmacology (Berl). 1978 Apr 14;57(1):63-9. doi: 10.1007/BF00426959.